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Latest Euradrenal news and research:
Euradrenal Final Symposium:
Addison’s disease, polyendocrine syndromes and beyond- update on research and clinical care
The symposium was arranged 7-9 March 2012 at Solstrand Hotel & Bad, at Os outside Bergen, Norway. The symposium brought together not only the consortium members and their teams, but also leaders in fields related to Addison’s disease from Europe and the United States. The programme was a combination of presentations of the latest science, state of the art clinical updates, and interactive workshops with patient organisations as active participators.
The Norwegian Society for Immunology has awarded Anette Bøe Wolff for her article in “The Journal of Experimental Medicine”.
Link to web site for the Committee’s recommendation and the article "Chronic mucocutaneous candidiasis in APECED or thymoma patients correlates with autoimmunity to Th17-associated cytokines:
Professor Olle Kämpe elected new member of The Royal Swedish Academy of Sciences
The Euradrenal partner Olle Kämpe is professor of molecular medicine at the Department of Medical Sciences at Uppsala University. Kämpe, who is working actively as a consultant in endocrinology, is also a highly recognised researcher in molecular medicine, immunology and endocrinology. His main area of research is autoimmune diseases, a field to which he has made huge contributions. This is an important field of medicine since one third of all morbidity and mortality in industrialised countries can be attributed to dysfunction in the immune system. His research team has identified a large number of autoantigens that have proved to be of great importance for diagnosis of autoimmune diseases. His findings also provide the basis for ongoing research into the development of new therapies. Lately his research has also included genetic and epidemiological studies in Addison’s disease and polyendocrine syndromes. The endocrine glands affected in the autoimmune diseases Kämpe and his team are studying are of vital importance for many basic functions in the body as metabolism of carbohydrates, proteins and fat, bone metabolism and the function of the immune system.
The press release from The Royal Swedish Academy of Science can be found here:
Latest Euradrenal Publications:
Autoantibody responses in autoimmune ovarian insufficiency and in Addison's disease are IgG1 dominated and suggest a predominant, but not exclusive, Th1 type of response.
The study analyzed IgG subclass specificity of autoantibodies directed against key autoantigens in Addison’s diseae and autoimmune ovarian failure. The Italian Euradrenal partners found that IgG1 autoantibodies dominated, which suggests a predominant T helper cell 1 response, which indicate that cytotoxic T cells are involved in autoimmune destruction of the adrenals and ovaries.
Published in: Eur J Endocrinol. 2010 Aug;163(2):309-17.
Link to publication
Review article on Cellular immunity and immunopathology in autoimmune Addison's disease.
Autoimmune adrenocortical failure, or Addison's disease, is a prototypical organ-specific autoimmune disorder. In common with related autoimmune endocrinopathies. The key to progress in treating and preventing autoimmune Addison's disease lies in improving our understanding of the predisposing factors, the mechanisms responsible for the progression of the disease, and the interactions between adrenal antigens and effector cells and molecules of the immune system. In this review article the current knowledge on the role of T cells and cellular immunity in the pathogenesis of autoimmune Addison's disease is summarised. Mol Cell Endocrinol. 2010 Dec 15
A CLEC16A variant confers risk for juvenile idiopathic arthritis and anti-cyclic citrullinated peptide antibody negative rheumatoid arthritis.
Variants in CLEC16A have conferred susceptibility to autoimmune diseases in genome-wide association studies. In this paper the involvement of CLEC16A was explored in juvenile idiopathic arthritis (JIA) rheumatoid arthritis (RA), type 1 diabetes (T1D) and Addison's disease (AD) in the Norwegian population. All diseases were associated with CLEC16A, but with different single nucleotide polymorphisms showing that different causative variants of CLEC16A underlie the rheumatic versus the organ specific diseases.
Published in: Ann Rheum Dis. 2010 Aug; 69(8):1471-4.
Link to publication
Sexuality and fertility in women with Addison's disease.
Females with primary adrenal insufficiency (Addison's disease) have reduced levels of circulating androgens, which are allegedly important for sexual functioning. The Addison's disease females were equally sexually active as the controls, but they reported significantly higher pleasure and less discomfort. The fertility was significantly reduced. Despite androgen depletion, females with Addison's disease do not report impaired sexuality. The fertility is reduced after the diagnosis is made; the reasons for this remain unknown.
Published in: J Clin Endocrinol Metab. 2010 Sep;95(9):4354-60. Epub 2010 Jul 7.
Link to publication
Development of a disease-specific quality of life questionnaire in Addison's disease.
Disease-specific questionnaires have proven a useful tool to evaluate the effects of interventions on health-related quality of life (HRQoL) in clinical trials. The aim was to develop a questionnaire that addresses HRQoL issues that are particularly relevant for patients with Addison disease (AD) and to select items likely to be sensitive to treatment effects. A 36-item questionnaire (AddiQoL) was constructed based on a literature search, interviews of patients with AD and their partners, and testing in a large patient population. The study clearly indicated that fatigue is a central HRQoL issue in patients with AD and that coping with emotional stress can be particularly challenging. Analysis of the responses indicated high internal consistency of the questionnaire and good targeting to the population. The ultimate aim will be utilise AddiQoL to evaluate effects on HRQoL of new treatments in AD.
This paper is cited in Nature Reviews Endocrinol: Link
Published in: J Clin Endocrinol Metab. 2010 Feb;95(2):545-51. Epub 2009 Dec 16.
Link to publication
European Addison's Conference
The Addison’s support groups for Denmark and Norway and Professor Eystein Husebye, University of Bergen, arranged a conference on Addison’s Disease 11 – 14 November 2010 in Bergen, Norway. The conference was attended by 10 European patient organisations and 7 physician in the Euradrenal network.
One of the main outcomes of the conference was to work to implement a common Addison identification card for use in medical emergencies in Europe.
Professor George Hollender has been appointed to the Action Research Professorship of Paediatrics, in the Department of Paediatrics, University of Oxford. Professor Hollander will keep a part of his position at Univesity of Basel. He will start his new position the 1st September 2010. Link to Oxford Univesity Gazette
Professor Eystein Husebye has been appointed Honorary Doctor of Medicine at Uppsala Universitetet
The Faculties of Medicine and Pharmacy at Uppsala university has October 1st decided to appoint Professor Eystein Husebye Honorary Doctor of Medicine. Link ... Read more
Bergensforskere starter Europeisk nettverk på hormonforskning finanisert av EU
[Norwegian] 16-18 april 2008 skal en rekke forskere samles i Bergen og Hardanger for å planlegge arbeidet med forskningsprosjektet Euradrenal. I prosjektet vil en studere både årsaker, utbredelse og behandling av sviktende binyrefunksjon, en sykdom som også kalles Addisons sykdom er. [ Les mer.. ]